4th scientific workshop for stakeholders: NPL, Teddington, United Kingdom, 20-21 May 2019

The final scientific workshop for stakeholders, entitled “European Workshop on the Clinical Implementation of Dosimetry for Molecular Radiotherapy”, took place at the National Physics Laboratory (NPL) in Teddington, United Kingdom, on 20-21 May 2019.

The workshop presented the final results of this project. New protocols for comparison of quantitative imaging and commissioning of a Molecular Radiotherapy (MRT) dose calculation platform were presented in the context of multi-centre comparison exercises performed within the project. The outputs from the project put into context with presentations covering activity measurement, quantitative imaging and dosimetry in a clinical environment, in support of clinical trials and from a commercial prospective. The latest guidance on dosimetry and quantitative imaging for MRT from the EANM, MIRD and ICRP were presented for discussion.

The workshop agenda and details are available hereAdobe Acrobat file.

Presentations for download (download allZIP file):

MRTDosimetry: a pan-European project establishing metrology for clinical implementation of dosimetry in molecular radiotherapyAdobe Acrobat file
Andrew Robinson, National Physical Laboratory, United Kingdom

New Activity Transfer Instrument: Can we improve the measurement of high-energy pure β-emitters in the hospitals?Adobe Acrobat file
Kelley Ferreira, National Physical Laboratory, United Kingdom

Clinical use of the secondary standard ion chamberAdobe Acrobat file
Steve Jeans, The Christie NHS Foundation Trust, United Kingdom

Activity calibration for clinical trials: alpha pharmaceuticalsAdobe Acrobat file
Erlend Eikeland Myrnes, Bayer AS, Norway

Calibration and verification of quantitative imaging using SPECT/CTAdobe Acrobat file
Johannes Tran-Gia and Michael Lassmann, University of Würzburg, Germany

Monte Carlo Simulation of SPECT ImagingAdobe Acrobat file
Gunjan Kayal, SCK.CEN, Belgium and INSERM, France

Towards a vendor-independent standard for absolute quantitative SPECT/CTAdobe Acrobat file
Steffie Peters, Radboud university medical center, The Netherlands

Imaging and dosimetry for Ho-166Adobe Acrobat file
Gerrit van de Maat, Quirem Medical, The Netherlands

Commissioning of a dosimetry platform for MRTAdobe Acrobat file
Jill Tipping and Nick Calvert, The Christie NHS Foundation Trust, United Kingdom

NTCP uncertaintiesAdobe Acrobat file
Maurice Cox, National Physical Laboratory, United Kingdom

EANM Dosimetry guidelines: Compliance to individual treatment planning in Molecular RadioTherapyAdobe Acrobat file
Mark Konijnenberg, Erasmus MC, Rotterdam, The Netherlands

Metrology for clinical implementation of dosimetry in molecular radiotherapy MIRDAdobe Acrobat file
Robert Hobbs, Johns Hopkins Medicine Department of Radiation Oncology, USA

ICRP Publication 140: Radiological protection in therapy with radiopharmaceuticalsAdobe Acrobat file
Glenn Flux, The Royal Marsden Hospital & Institute of Cancer Research, United Kingdom

Database of reference images and DICOM conversion toolAdobe Acrobat file
Andrew Robinson, National Physical Laboratory, United Kingdom

Final comments from a medical perspectiveAdobe Acrobat file
Markus Luster, University of Marburg, Germany

2nd scientific workshop for stakeholders: Prague, Czech Republic, 26-27 September 2018

The second scientific workshop for stakeholders, entitled “European workshop on the principles and clinical implementation of dose calculation in molecular radiotherapy”, took place in Prague, Czech Republic, on 26-27 September 2018.

The workshop agenda, advert, and logistical information are available hereAdobe Acrobat file.

The workshop focused on the clinical implementation and supporting principals of molecular radiotherapy (MRT) dose calculations. Emphasis was given to presentation and discussion of dose calculation methods implemented in a clinical setting and to the treatment of uncertainty in clinical calculations.

Presentations for download (list with linksAdobe Acrobat file; download allZIP file):

Introduction to MRTDosimetry projectAdobe Acrobat file
   Andrew Robinson, NPL, United Kingdom

Invited talk: Dosimetry in Clinical Trial Design: Making the caseAdobe Acrobat file
   George Sgouros, John Hopkins University, United States

Invited talk: Methods for determining uncertainty in clinical dose calculation: TheoryAdobe Acrobat file
   Maurice Cox, NPL, United Kingdom

Invited talk: Methods for determining uncertainty in clinical dose calculation: PracticeAdobe Acrobat file
   Jonathan Gear, Institute of Cancer Research, United Kingdom

Invited talk: Quantitative imaging and dose calculation comparison exercises in the MRTDosimetry projectAdobe Acrobat file
   Johannes Tran-Gia, Universitätsklinikum Würzburg, Germany
   Nick Calvert, The Christie NHS Foundation Trust, United Kingdom

Invited talk: Review of dose calculation methods: implications for future clinical implementationAdobe Acrobat file
   Alex Vergara-Gil, INSERM, France

Invited talk: Clinical dosimetry with 99mTc-MAA for 90Y SIRT: practical methods and resultsAdobe Acrobat file
   Francesca Botta, European Institute of Oncology, Italy

PBPK/PD modelling for predicting tumour responseAdobe Acrobat file
   Peter Kletting, Ulm University, Germany

Personal experience with dosimetry attemptsAdobe Acrobat file
   Pavel Solný, National Radiation Protection Institute, Czech Republic

Comparison between a convolution based and Monte Carlo based dosimetry softwareAdobe Acrobat file
   Domenico Finocchiaro, AUSL-IRCCS Reggio Emilia, Italy

Calculation methods in Hermes Medical Solutions’ dosimetry softwareAdobe Acrobat file
   Helena McMeekin, Hermes Medical Solutions, United Kingdom

The experience in a single institute over two decades of individualized radiopeptide therapy: from bench to bedsideAdobe Acrobat file
   Georgios S. Limouris, National and Kapodistrian University of Athens, Greece

Performing post treatment patient specific dosimetry in peptide receptor radionuclide therapy with 177Lutetium-DOTATATE, using software package by MIM Software Inc.Adobe Acrobat file
   Maria Kotzassarlidou, “Theagenio” Anticancer Hospital of Thessaloniki, Greece

The OpenDose CollaborationAdobe Acrobat file
   Maxime Chauvin, INSERM, France

A novel segmentation method for advanced personalised 3D image-base dosimetry in Peptide Receptor Radionuclide TherapyAdobe Acrobat file
   Salvatore Berenato, Cardiff University, United Kingdom

Challenges in post-treatment dose calculations using image-based quantification of Y-90 SPECT/CT dataAdobe Acrobat file
   Konrad Lotter, Technische Universität Wien, Austria

Dosimetry in Czechoslovakia – forgotten history in the light of uprising dosimetryAdobe Acrobat file
   Pavel Solný, National Radiation Protection Institute, Czech Republic

This slideshow requires JavaScript.

Full resolution group photograph

A movie: Radioactive Iodine Therapy for Thyroid Cancer at Motol University Hospital, Czech Republic, ~1960 – will be uploaded soon…

1st scientific workshop for stakeholders: Vienna, Austria, 5-6 April 2017

The first scientific workshop for stakeholders “European Workshop on Quantitative Imaging for molecular radiotherapy – metrology for clinical practice” took place in BEV, Vienna, Austria, 5-6 April 2017.

Workshop agenda is available here Adobe Acrobat file.

The workshop was focused on calibration and validation of quantitative imaging for dosimetry in molecular radiotherapy as well as providing an introduction and overview of the EMPIR MRTDosimetry project devoted to providing state of the art dosimetry and protocols for clinical practice.

Emphasis was given to presentation and discussion of methods currently implemented at different centres and establishing an effective forum for discussion.  The aim of the workshop was to agree on standard calibration methods that can be developed by the MRTDosimetry project as the basis of an international dosimetry protocol. It is important that the experience of the MRT community is represented as widely as possible.

Presentations for download:

Methodology and results of planar calibration with I-131 and Lu-177… With potential implication on SPECTAdobe Acrobat file (Carlo Chiesa, Italy)

Towards a quality assurance for dosimetry in fractionated molecular radiotherapyAdobe Acrobat file (Gwennaelle Marin, Belgium)

IAEA activities in the field of dosimetry for Radiopharmaceutical TherapyAdobe Acrobat file (Gian Luca Poli, IAEA)

Quality assurance of activity administration in Selective Internal Radiation TherapyAdobe Acrobat file (Hugo Levillain, Belgium)

Quantitative Imaging: A hospital physicist’s perspectiveAdobe Acrobat file (James Scuffham, United Kingdom)

Traceable Quantification for Ga-68 based PET/CTAdobe Acrobat file (Kristof Baete, Belgium)

Uniformity testing of gamma cameras at high count-ratesAdobe Acrobat file (Nick Bates, United Kingdom)

Stumbling towards (accurate) quantitative imagingAdobe Acrobat file (Stephan Witoszynskyj, Austria)

“Theagenio” Hospital of Thessaloniki – Nuclear Medicine Department’s methods for Ra-223 and I-131 dosimetryAdobe Acrobat file (Maria Kotzasarlidou, Greece)