Events – MRTDosimetry

4th scientific workshop for stakeholders: NPL, Teddington, United Kingdom, 20-21 May 2019

The final scientific workshop for stakeholders, entitled “European Workshop on the Clinical Implementation of Dosimetry for Molecular Radiotherapy”, took place at the National Physics Laboratory (NPL) in Teddington, United Kingdom, on 20-21 May 2019.

The workshop presented the final results of this project. New protocols for comparison of quantitative imaging and commissioning of a Molecular Radiotherapy (MRT) dose calculation platform were presented in the context of multi-centre comparison exercises performed within the project. The outputs from the project put into context with presentations covering activity measurement, quantitative imaging and dosimetry in a clinical environment, in support of clinical trials and from a commercial prospective. The latest guidance on dosimetry and quantitative imaging for MRT from the EANM, MIRD and ICRP were presented for discussion.

The workshop agenda and details are available here Adobe Acrobat file .

Presentations for download (download all):

MRTDosimetry: a pan-European project establishing metrology for clinical implementation of dosimetry in molecular radiotherapy Adobe Acrobat file
Andrew Robinson, National Physical Laboratory, United Kingdom

New Activity Transfer Instrument: Can we improve the measurement of high-energy pure β-emitters in the hospitals? Adobe Acrobat file
Kelley Ferreira, National Physical Laboratory, United Kingdom

Clinical use of the secondary standard ion chamber Adobe Acrobat file
Steve Jeans, The Christie NHS Foundation Trust, United Kingdom

Activity calibration for clinical trials: alpha pharmaceuticals Adobe Acrobat file
Erlend Eikeland Myrnes, Bayer AS, Norway

Calibration and verification of quantitative imaging using SPECT/CT Adobe Acrobat file
Johannes Tran-Gia and Michael Lassmann, University of Würzburg, Germany

Towards a vendor-independent standard for absolute quantitative SPECT/CT Adobe Acrobat file
Steffie Peters, Radboud university medical center, The Netherlands

Imaging and dosimetry for Ho-166 Adobe Acrobat file
Gerrit van de Maat, Quirem Medical, The Netherlands

Commissioning of a dosimetry platform for MRT Adobe Acrobat file
Jill Tipping and Nick Calvert, The Christie NHS Foundation Trust, United Kingdom

NTCP uncertainties Adobe Acrobat file
Maurice Cox, National Physical Laboratory, United Kingdom

EANM Dosimetry guidelines: Compliance to individual treatment planning in Molecular RadioTherapy Adobe Acrobat file
Mark Konijnenberg, Erasmus MC, Rotterdam, The Netherlands

Metrology for clinical implementation of dosimetry in molecular radiotherapy MIRD Adobe Acrobat file
Robert Hobbs, Johns Hopkins Medicine Department of Radiation Oncology, USA

ICRP Publication 140: Radiological protection in therapy with radiopharmaceuticals Adobe Acrobat file
Glenn Flux, The Royal Marsden Hospital & Institute of Cancer Research, United Kingdom

Database of reference images and DICOM conversion tool Adobe Acrobat file
Andrew Robinson, National Physical Laboratory, United Kingdom

Final comments from a medical perspective Adobe Acrobat file
Markus Luster, University of Marburg, Germany

3rd scientific workshop for stakeholders: Thessaloniki, Greece, 10 May 2019

Posted on 10|0422|05 by Jaroslav Šolc

The scientific workshop entitiled “Molecular Radiotherapy Dosimetry: Clinical Implementation of Personalised Dosimetry in Molecular Radiotherapy” was held on 10th May 2019 in amphitheater of “THEAGENIO” Cancer Hospital in Thessaloniki, Greece.

The workshop agenda is available here Adobe Acrobat file .

The final project meeting, Thessaloniki, Greece, 8-9 May 2019

Posted on 01|1022|05 by Jaroslav Šolc

The final project meeting was held in Thessaloniki, Greece, on 8-9 May 2019. The meeting agenda and logistical information are available here Adobe Acrobat file .

On 10 May the meeting was followed by one-day workshop for stakeholders.

Also, there was another project workshop for stakeholders that was held on 20-21 May 2019 at National Physics Laboratory in Teddington, United Kingdom.

2nd scientific workshop for stakeholders: Prague, Czech Republic, 26-27 September 2018

Posted on 15|0101|10 by Jaroslav Šolc

The second scientific workshop for stakeholders, entitled “European workshop on the principles and clinical implementation of dose calculation in molecular radiotherapy”, took place in Prague, Czech Republic, on 26-27 September 2018.

The workshop agenda, advert, and logistical information are available here Adobe Acrobat file .

The workshop focused on the clinical implementation and supporting principals of molecular radiotherapy (MRT) dose calculations. Emphasis was given to presentation and discussion of dose calculation methods implemented in a clinical setting and to the treatment of uncertainty in clinical calculations.

Presentations for download (list with links; download all):

Introduction to MRTDosimetry project Adobe Acrobat file
Andrew Robinson, NPL, United Kingdom

Invited talk: Dosimetry in Clinical Trial Design: Making the case Adobe Acrobat file
George Sgouros, John Hopkins University, United States

Invited talk: Methods for determining uncertainty in clinical dose calculation: Theory Adobe Acrobat file
Maurice Cox, NPL, United Kingdom

Invited talk: Methods for determining uncertainty in clinical dose calculation: Practice Adobe Acrobat file
Jonathan Gear, Institute of Cancer Research, United Kingdom

Invited talk: Quantitative imaging and dose calculation comparison exercises in the MRTDosimetry project Adobe Acrobat file
Johannes Tran-Gia, Universitätsklinikum Würzburg, Germany
Nick Calvert, The Christie NHS Foundation Trust, United Kingdom

Invited talk: Review of dose calculation methods: implications for future clinical implementation Adobe Acrobat file
Alex Vergara-Gil, INSERM, France

Invited talk: Clinical dosimetry with 99mTc-MAA for 90Y SIRT: practical methods and results Adobe Acrobat file
Francesca Botta, European Institute of Oncology, Italy

PBPK/PD modelling for predicting tumour response Adobe Acrobat file
Peter Kletting, Ulm University, Germany

Personal experience with dosimetry attempts Adobe Acrobat file
Pavel Solný, National Radiation Protection Institute, Czech Republic

Comparison between a convolution based and Monte Carlo based dosimetry software Adobe Acrobat file
Domenico Finocchiaro, AUSL-IRCCS Reggio Emilia, Italy

Calculation methods in Hermes Medical Solutions’ dosimetry software Adobe Acrobat file
Helena McMeekin, Hermes Medical Solutions, United Kingdom

The experience in a single institute over two decades of individualized radiopeptide therapy: from bench to bedside Adobe Acrobat file
Georgios S. Limouris, National and Kapodistrian University of Athens, Greece

Performing post treatment patient specific dosimetry in peptide receptor radionuclide therapy with 177Lutetium-DOTATATE, using software package by MIM Software Inc. Adobe Acrobat file
Maria Kotzassarlidou, “Theagenio” Anticancer Hospital of Thessaloniki, Greece

The OpenDose Collaboration Adobe Acrobat file
Maxime Chauvin, INSERM, France

A novel segmentation method for advanced personalised 3D image-base dosimetry in Peptide Receptor Radionuclide Therapy Adobe Acrobat file
Salvatore Berenato, Cardiff University, United Kingdom

Challenges in post-treatment dose calculations using image-based quantification of Y-90 SPECT/CT data Adobe Acrobat file
Konrad Lotter, Technische Universität Wien, Austria

Dosimetry in Czechoslovakia – forgotten history in the light of uprising dosimetry Adobe Acrobat file
Pavel Solný, National Radiation Protection Institute, Czech Republic

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Full resolution group photograph

A movie: Radioactive Iodine Therapy for Thyroid Cancer at Motol University Hospital, Czech Republic, ~1960 – will be uploaded soon…

4th project meeting, Prague, Czech Republic, 24-25 September 2018

Posted on 15|0110|04 by Jaroslav Šolc

The fourth project meeting was held in Prague, Czech Republic, on 24-25 September 2018. The meeting was followed by the second workshop for stakeholders. The meeting agenda is available here Adobe Acrobat file and logistical information is available here.

3rd project meeting, Toulouse, France, 20-21 November 2017

Posted on 20|0429|03 by Jaroslav Šolc

The third project meeting was held in Toulouse, France, 20-21 November 2017. Meeting agenda is available here Adobe Acrobat file .

1st scientific workshop for stakeholders: Vienna, Austria, 5-6 April 2017

Posted on 22|0701|10 by Jaroslav Šolc

The first scientific workshop for stakeholders “European Workshop on Quantitative Imaging for molecular radiotherapy – metrology for clinical practice” took place in BEV, Vienna, Austria, 5-6 April 2017.

Workshop agenda is available here Adobe Acrobat file .

The workshop was focused on calibration and validation of quantitative imaging for dosimetry in molecular radiotherapy as well as providing an introduction and overview of the EMPIR MRTDosimetry project devoted to providing state of the art dosimetry and protocols for clinical practice.

Emphasis was given to presentation and discussion of methods currently implemented at different centres and establishing an effective forum for discussion. The aim of the workshop was to agree on standard calibration methods that can be developed by the MRTDosimetry project as the basis of an international dosimetry protocol. It is important that the experience of the MRT community is represented as widely as possible.

Presentations for download:

Methodology and results of planar calibration with I-131 and Lu-177… With potential implication on SPECT Adobe Acrobat file (Carlo Chiesa, Italy)

Towards a quality assurance for dosimetry in fractionated molecular radiotherapy Adobe Acrobat file (Gwennaelle Marin, Belgium)

IAEA activities in the field of dosimetry for Radiopharmaceutical Therapy Adobe Acrobat file (Gian Luca Poli, IAEA)

Quality assurance of activity administration in Selective Internal Radiation Therapy Adobe Acrobat file (Hugo Levillain, Belgium)

Quantitative Imaging: A hospital physicist’s perspective Adobe Acrobat file (James Scuffham, United Kingdom)

Traceable Quantification for Ga-68 based PET/CT Adobe Acrobat file (Kristof Baete, Belgium)

Uniformity testing of gamma cameras at high count-rates Adobe Acrobat file (Nick Bates, United Kingdom)

Stumbling towards (accurate) quantitative imaging Adobe Acrobat file (Stephan Witoszynskyj, Austria)

“Theagenio” Hospital of Thessaloniki – Nuclear Medicine Department’s methods for Ra-223 and I-131 dosimetry Adobe Acrobat file (Maria Kotzasarlidou, Greece)